The Evidence-based guidelines for the pharmacological treatment of migraine were created by the Italian Society for the Study of Headache and the International Headache Society, and aim to offer clear, actionable recommendations to healthcare professionals.

The guidelines incorporate evidence-based recommendations from randomized controlled trials and expert-based opinions. They follow the Grading of Recommendations, Assessment, Development and Evaluation approach for assessing the quality of evidence.

The guideline development involved a systematic review of literature across multiple databases, adherence to Cochrane review methods, and a structured framework for data extraction and interpretation. Although the guidelines provide a robust foundation for migraine treatment, they also highlight gaps in current research, such as the paucity of head-to-head drug comparisons and the need for long-term outcome studies. These guidelines serve as a resource to standardize migraine treatment and promote high-quality care across different healthcare settings.

Read and download the guidelines here.